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Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.
Preface to the First EditionIntroduction1. Basic Information Antiserum Antigens The Precipitin Reaction Other Serologic Reactions Diffusion Electrophoresis Other Methods of Reactant Migration2. General Information Antiserum Antigen Immunization Protocols Collection and Care of Antiserum Nonantibody Precipitins Preparation of Antigens Media for Immunodiffusion Composition of Immunodiffusion Test Solvents Environmental Conditions for Immunodiffusion Tests Apparatus Reaction Enhancement Nonspecific Precipitation in Immunodiffusion Tests Washing and Staining Immunodiffusion Patterns Observing Recording, and Photographing Immunodiffusion Reactions3. Single Diffusion Tests Mechanisms of Single Diffusion Tests Selected Single Diffusion Techniques Conclusion4. Double Diffusion Tests Characteristics and Mechanisms Selected Double Diffusion Techniques Sensitivity of Double Diffusion Tests5. Immunoelectrophoresis Theory and Interpretation of Immunoelectrophoresis Immunoelectrophoresis Techniques6. Electroimmunodiffusion History Theory and Mechanisms Techniques7. Ancillary Immunodiffusion Techniques Alternative Methods for Detecting Antigen-Antibody Reactions Auxiliary Indicators for Antigen-Antibody Reaction Novel Varieties of Immunodiffusion8. HistoryReferencesGlossaryAppendix I. AdjuvantsAppendix U. Selected Immunodiffusion Electrolyte SolutionsAppendix III. Selected Inmiunoelectrophoresis and Electroinmiunodiffusion BuffersAppendix IV. Immunochromatography BuffersAppendix V. Selected Protein StainsAppendix VI. Selected Lipid StainsAppendix VII. Selected Polysaccharide Stains Appendix VIII. Selected Nucleic Acid StainsAppendix IX. Selected Double StainsSubject Index
