Cellular and Molecular Mechanisms of Inflammation

Receptors of Inflammatory Cells: Structure-Function Relationships is the first in a new serial on Cellular and Molecular Mechanisms of Inflammation. The purpose of this serial is to bring together the latest knowledge in various areas of research in this actively developing field around a topical focus. These volumes are not intended to present comprehensive reviews. Rather, each contribution is meant to be a status report from laboratories actively working in an area. This volume presents an analysis of the structure-function relationships of receptors. It is clear that the structure of receptors provides the initial guidance for numerous functions of each cell in the organism. Through an analysis of the submolecular features of the receptors that are responsible for the initiation of activity of diverse biochemical pathways within the cells, a molecular understanding of the all important initial, guiding events of cell functions will emerge. In the broad sense of cells involved in inflammation, this includes mitogenesis, gene transcription, generation of lipid metabolites and oxidants, clearance of molecules from the surrounding medium, and release of granular constituents from cytoplasmic vesicles into the external medium, among others. The contents of this first volume will serve as a foundation for the subject of the second volume, which is signal transduction. Four additional volumes are in preparation, including Endothelial Leukocyte-Adhesion Molecules, Leukocyte Adhesive Mechanisms in Inflammation and Immunity, a second volume on Signal Transduction, and Stimulation of Inflammatory Cells.

PrefaceChapter 1 FC- Receptors: A Diverse and Multifunctional Gene Family Introduction Nomenclature huFc-RI huFc-RII huFc-RIII moFc-RI moFc-RII Fc-R Cycling Fc-R Signaling Soluble Fc-Rs Autoimmunity ReferencesChapter 2 Genetic Analysis of ß-Adrenergic Receptor Structure and Function Introduction Receptor Structure Ligand-Binding Domain G Protein Coupling Conclusions and Future Directions ReferencesChapter 3 CR1 and CR2: Receptors Mediating Cellular Recognition in the Complement System Overview CR1 CR2 ReferencesChapter 4 N-Formyl Peptide Receptor Structure-Function Relationships Introduction Receptor Purification and Reconstitution Physicochemical Properties of the Receptor Receptor Structure Receptor Heterogeneity Control of Cell Surface Receptor Numbers Cellular Processing of Receptor and Ligand Molecular Interactions of the Receptor Summary ReferencesChapter 5 Influenza A Virus Activation of the Human Neutrophil: A Case of Promiscuous Binding? Introduction Hemagglutinin Structure Hemagglutinin and Its Receptor Effect of Competing Sugars on Neutrophil Activation by IAV and Other Stimuli Effects of Preincubation with Neuraminidase on Neutrophil Activation by IAV and WGA Viral Binding Discussion ReferencesChapter 6 Structure and Function of Murine and Human IL-1 Receptors Introduction Structure of Murine and Human IL-1 Receptors Interaction of IL-1 Receptor with IL-1s IL-1 Receptor Heterogeneity Signal Transduction through the IL-1 Receptor and Postreceptor Events IL-1 Receptor Regulation Summary ReferencesChapter 7 Structure and Function of the High-Affinity Receptor for Immunoglobulin E Introduction Receptor Structure Receptor-IgE Interactions IgE Receptor Cross-Linking IgE Receptor-Mediated Signal Transduction Future Directions ReferencesChapter 8 Signal Transduction by the PDGF Receptor Introduction Role of PDGF in Vivo Structure of the PDGF Receptor Cellular Responses to PDGF PDGF Stimulation of Gene Expression Concluding Remarks ReferencesChapter 9 IL-6 Receptor Introduction Binding Properties and Distribution of IL-6R Structure of IL-6R Regulation of IL-6R Expression IL-6-Induced Association of IL-6R and gp130 Signal Transducer of IL-6R, gp130 A Novel Mechanism of Cytokine-Mediated Signal Transduction ReferencesIndex