Immunity, Cancer, and Chemotherapy

Immunity, Cancer, and Chemotherapy focuses on the interference of drugs on antibody response and transplantation immunity. The selection first offers information on the effects of immunosuppressive drugs on cellular changes after antigenic stimulation and specialized cell function in the lymphoid and reticuloendothelial cell series. Topics include effects of immunosuppressive drugs on the sensitization process; cellular changes in lymphoid tissue following sensitization; and demonstration of differences in antigen handling among cells of the reticuloendothelial system. The text also takes a look at allogeneic inhibition and its possible relation to cell-bound immunity in vitro and the effects of immunosuppressive drugs at various stages of differentiation of immunologically competent cells. The publication examines a study of antibody-containing cells in the course of immunization and cellular differentiation during immune responses studied with electron microscope and radioautography. The text also elaborates on ambiguity in the translation of genetic code into proteins, induced by aminoglycoside antibiotics and immunosuppressive agents and cellular kinetics of immune response. The selection is a dependable source of information for readers interested in effects of drugs on antibody response and transplantation immunity.

articipantsList of ContributorsForewordPrefaceThe Effect Of Immunosuppressive Drugs On Cellular Changes After Antigenic Stimulation I. Cellular Changes In Lymphoid Tissue Following Sensitization II. Effect of Immunosuppressive Drugs on the Sensitization Process III. Conclusions References DiscussionSpecialized Cell Function In The Lymphoid And Reticuloendothelial Cell Series I. Demonstration of Differences In Antigen Handling Among Cells of the Reticuloendothelial System II. Specialization of Cells of the Lymphoid System III. Concluding Remarks References DiscussionAllogeneic Inhibition And Its Possible Relation To Cell-Bound Immunity In Vitro I. Attempts to Demonstrate Allogenic Inhibition in Vitro II. Summary Acknowledgments References DiscussionThe Effect Of Immunosuppressive Drugs At Various Stages Of Differentiation Of Immunologically Competent Cells I. Definition Of The Inductive Phase By The Use Of Metabolic Inhibitors II. The Influence Of Metabolic Inhibitors On Antibody Production III. The Influence Of Inhibitors On The Preparation For The Secondary Response IV. The Influence Of Inhibitors On The Secondary Response V. Studies On Immunological Inhibition (Tolerance) Using Metabolic Inhibitors VI. Unitarian Concept Of Immune Reactions Based On The Model Of Immunological Cell Differentiation References DiscussionA Study Of Antibody-Containing Cells In The Course Of Immunization I. Comparison Between The Results Obtained With The ICA And The Hemolysis Plaque Formation Techniques II. Application Of The ICA Method To The Study Of Cells Producing Antibodies Against Haptens III. Inhibition Of ICA By Heterologous Antibodies Against Immunoglobulins IV. Kinetics Of The Appearance Of "Rosette"-Forming Cells In The Spleen Of Mice Immunized Intravenously With Sheep Erythrocytes References DiscussionCellular Differentiation During Immune Responses Studied With The Electron Microscope And Radioautography Text References DiscussionConcerning The Recognition Reaction And Transfer RNA In Protein Synthesis Text References DiscussionAmbiguity In The Translation Of The Genetic Code Into Proteins, Induced By Aminoglycoside Antibiotics Text References DiscussionMacrophage RNA And Antibody Synthesis Text References DiscussionThe Role Of Antigen In The Regulation Of Antibody Formation I. Kinetics Of Antibody Formation To Bacteriophage -X 174 In Guinea Pigs II. Immune Functions of Individual Antibody-Forming Cells References DiscussionAlteration Of Immunity By Antimetabolites Text References DiscussionImmunosuppressive Agents And The Cellular Kinetics Of The Immune Response I. Introduction II. Materials And Methods III. Results IV. Discussion V. Summary References DiscussionImmunochemical Studies Of Mammalian Cell Membranes I. Introduction II. The Immunochemical Problem III. Methods For The Preparation Of Plasma Membranes IV. Recognition Marker For Plasma Membrane V. Composition Of Plasma Membrane Preparations VI. General Discussion References DiscussionTumor Antigens Text References DiscussionExpression Of Antigens In Normal Mammalian Cells I. Introduction II. Cellular Antigens In Tissue Culture III. Embryonic Differentiation Of Antigens IV. Induction Of Antigens In The Thymus V. Modification Of The Expression Of Normal Tissue Antigens In Vivo VI. Differentiation Of Immunoglobulin-Producing Cells VII. Closing Comments References DiscussionMechanism Of Complement Action And Means Of Complement Depletion I. Physiogenic And Pathogenic Role Of Complement II. Mechanism Of Action Of Human Complement III. Enhancement Of Complement IV. Inhibition Of Complement V.