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Interleukin 3: The Panspecific Hemopoietin contains contributions from immunologists, hematologists, protein chemists, and molecular biologists whose efforts have defined the biology and molecular nature of interleukin 3 (IL-3) in less than a decade. The articles represent personal perspectives rather than exhaustive reviews. They are arranged in alphabetical order rather than thematically because many of the individual articles cover multiple aspects of the molecule. These articles cover topics such as the potential role of IL-3 in the pathology of allergic and inflammatory disease and the role of IL-3 in the genesis of certain myeloid leukemias. A number of articles also highlight an important technical point, namely, that many of the various assays often used for IL-3 are not specific. One article indicates that the ""histamine-producing cell-stimulating factor"" activity can be mediated not only by IL-3 but also by granulocyte-macrophage colony-stimulating factor. Another deals with the lack of specificity of assays based on the induction of 20--SDH or factor-dependent cell lines.
PrefaceMolecular Structure and Biological Activities of P Cell-Stimulating Factor (Interieukin 3) I. Introduction II. History and Nomenclature III. Cellular Sources and Assays IV. Biological Activities V. Characterization, Purification, and Structure VI. Structure-Function Studies Approached by Peptide Synthesis VII. Summary ReferencesHistamine-Producing Cell-Stimulating Factor (HCSF) and Interieukin 3 (IL-3): Their Effects on Histidine and Ornithine Decarboxylases I. Introduction II. Evidence for a Lymphokine Increasing Histamine Synthesis: Histamine-Producing Cell-Stimulating Factor III. Interieukin 3 (IL-3) and Histamine-Producing Cell-Stimulating Factor IV. Interieukin 3 and Arginine Metabolism in Hemopoietic Cells V. Summary VI. Addendum ReferencesIL-3 and the Development of Cultured (Mucosal) Mast Cells in the Rat I. Introduction II. Mast Cells In Vivo and In Vitro III. IL-3-Like Activity in the Rat IV. The Target Cells Responding to IL-3 V. Maturation of IL-3-Dependent Cell Types VI. Conclusions and Speculations: IL-3 and MMC in Disease VII. Addendum ReferencesMolecular Biology of Interleukin 3: A Multilineage Hemopoietic Growth Regulator I. Introduction II. Biological Properties of Interleukin 3 III. Assays for Interleukin 3 IV. Isolation of cDNA Clones for Murine Interleukin 3 V. Cloning of the Gene for Murine Interleukin 3 VI. Expression from Recombinant DNA Constructs VII. Cloning of the Rat and Human Interleukin 3 Genes VIII. Interleukin 3 and Leukemia IX. Monoclonal Antibodies to Interleukin 3 X. Conclusion ReferencesImmunological Regulation of Hematopoietic Stem Cell Function by Interleukin 3 and Its Role in Leukemogenesis I. Introduction II. Sequence of IL-3-Supported Differentiation In Vitro III. Relationship of IL-3-Regulated Growth and Differentiation to Leukemogenesis IV. Mechanisms in IL-3-Regulated Differentiation V. Mechanisms in IL-3-Regulated Growth VI. Conclusions and Speculations ReferencesThe Expression and Characterization of Recombinant Mouse IL-3 I. Introduction II. Expression of IL-3 in Mammalian Cells III. Expression of IL-3 in Escherichia Coli IV. Expression of IL-3 in Yeast V. Conclusion ReferencesThe Multipotential Colony-Stimulating Factor, Multi-CSF (IL-3) I. Terminology II. Review of Work on Multi-CSF in This Laboratory III. Biochemical Nature and Molecular Biology of Multi-CSF IV. Tissue Sources of Multi-CSF V. Membrane Receptors for Multi-CSF VI. Biological Actions in Vitro of Multi-CSF VII. In Vivo Fate of Multi-CSF VIII. In Vivo Effects of Injected Bacterially Synthesized Multi-CSF IX. Does Multi-CSF Play a Special Role in Leukemogenesis? X. Is There a Human Analog of Murine Multi-CSF? XI. Summary ReferencesInterieukin 3: An Overview I. Introduction II. Cellular Origins of Interieukin 3 III. Biochemical and Molecular Aspects IV. Interleukin 3 Receptor Characterization V. Interleukin 3 in Myeloid Differentiation VI. Interleukin 3 Action in Erythropoiesis VII. Interleukin 3 Action in Megakaryocytopoiesis VIII. Interleukin 3: A Mast Cell and Basophil Growth Factor IX. Interleukin 3 and Natural Cytotoxic Cells X. The Role of Interleukin 3 in - Cell Development XI. Interleukin 3 Action on Pluripotential Stem Cells XII. Interleukin 3 and the Proliferation of Factor-Dependent Cell Lines XIII. In Vivo Action of Interleukin 3 XIV. Interleukin 3 and Murine Myeloid Leukemia-Autocrine Regulation XV. Conclusion ReferencesThe Panspecific Hemopoietin Interleukin 3: Physiology and Pathology I. Introduction II. Production of IL-3 In Vivo III. Clearance of IL-3 from the Blood IV. Action of IL-3 In Vivo V. Mechanism of Action of IL-3 VI. Pathological Role of IL-3 VII.
