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Motor System Disorders, Volume 195, Part One, Normal Physiology and Function and Neuromuscular Disorders summarizes recent advances and best practice for understanding normal physiology and function of the larger motor system as well as the diagnosis, course, and treatment of neuromuscular disorders. The work includes neuroanatomy, circuits, and synapses, and discusses how different parts of the brain contribute to motor control, including both vestibular and cerebellar motor control, as well as the influences of the parietal and frontal lobes. Diagnostic methods include genetic evaluation, electrodiagnosis, pathology, and brain imaging. Neuromuscular disorders of both children and adults are included.
Section 1. Normal Physiology and Function 1. Skeletal muscle structure, physiology, and function 2. Upper and lower motor neuron neurophysiology and motor control 3. Vestibular motor control 4. Autonomic failure: Clinicopathologic, physiologic, and genetic aspects 5. Gait control by the frontal lobe 6. Parietal control of hand movement 7. Immunology and microbiome: Implications for motor systems 8. COVID-19 (novel SARS-CoV-2) neurological illness Section 2. Clinical and Laboratory Diagnosis 9. Neurogenetic motor disorders 10. Neuromuscular electrodiagnosis 11. Quantitative electrodiagnosis of the motor unit 12. Neuromuscular pathology 13. Electrophysiological assessment of peripheral and central autonomic disorders 14. On the path to evidence-based therapy in neuromuscular disorders 15. Advances in the neuroimaging of motor disorders 16. Sleep-related motor disorders Section 3. Neuromuscular Disorders 17. Neonatal and infantile hypotonia 18. Autoimmune inflammatory myopathies 19. Childhood muscular dystrophies 20. Distal myopathy 21. Muscle channelopathies 22. Congenital myopathies 23. Mitochondrial encephalomyopathy 24. Autoimmune polyneuropathies 25. Hereditary neuropathy 26. Acute/chronic inflammatory polyradiculoneuropathy 27. Myasthenia gravis and congenital myasthenic syndromes 28. Adult and childhood vasculitis 29. Critical illness-associated weakness and related motor disorders
