Nutrition, Aging, and Artificial Organs

Methods of Animal Experimentation, Volume V: Nutrition, Aging, and Artificial Organs is a collection of papers that deals with methods to be used in animal experiments to achieve cost effectiveness in their use. This collection discusses laboratory animals used in different experiments such as in nutritional research, aging studies, and artificial organ research. The papers describe the species of animals appropriate for the kind of experiment to be conducted and the criteria that should be followed in choosing a certain species. These criteria include their growth rate, stage of development, as well as existing performance variations. In determining test animals for aging experiments, the book recommends that complete data be available on the genetics of the species, strain, diet history, environmental factors, breeding, and spontaneous diseases to approximate the best test results. The book addresses that the aged are more susceptible to inputs than the young in terms of morphological and functional age. In selecting test animals for artificial organ research, the book notes the importance of animal selection that will be determined, for example, by 1) the size of the prosthesis; 2) the amount of blood flow needed for the device differs in animals and man; and 3) the surgical techniques that will be employed. This book will prove helpful for laboratory workers, veterinarians, and technicians working with laboratory animals. This collection will also be appreciated by researchers designing medical and scientific tests.

List of ContributorsPrefaceContents of Previous VolumesChapter 1 Laboratory Animals in Nutritional Research I. Species of Animals Used II.. Criteria for Choosing Species III. Feeding Procedures IV. Example of Laboratory Animal Research in Nutrition ReferencesChapter 2 Laboratory Animals in Aging Studies I. Introduction II. Factors to Be Considered in Gerontological Studies III. Summary ReferencesChapter 3 Use of Laboratory Animals in Artificial Organ Research I. Introduction II. General Problems Associated with Artificial Organs Experiments III. Extracorporeal Circulation IV. Material Studies V. Vascular Prostheses VI. Model of Disease in Cardiovascular Research VII. Pacemakers VIII. Artificial Heart Valves IX. A Total Artificial Heart X. Assisted Circulation XI. Oxygenators XII. Artificial Kidney -III. Other Implantable Artificial Organs and Tissues ReferencesAuthor IndexSubject Index