Drugs in Psychiatric Practice

Dr. Sam Stuart is a physiotherapist and a research Fellow within the Balance Disorders Laboratory, OHSU. His work focuses on vision, cognition and gait in neurological disorders, examining how technology-based interventions influence these factors. He has published extensively in world leading clinical and engineering journals focusing on a broad range of activities such as real-world data analytics, algorithm development for wearable technology and provided expert opinion on technology for concussion assessment for robust player management. He is currently a guest editor for special issues (sports medicine and transcranial direct current stimulation for motor rehabilitation) within Physiological Measurement and Journal of NeuroEngineering and Rehabilitation, respectively.

Introduction1 Classification of Psychotropic Drugs What is a Psychotropic Drug? Types of Classification Classification of Drugs Used in This Book2 Pharmacokinetics and Drug Metabolism-Basic Principles Definitions and Basic Principles in Pharmacokinetics Absorption Protein Binding and Distribution Metabolism Excretion Pharmacokinetics and Pharmacological Effect Conclusions3 Evaluation of Psychotropic Drugs Animal Studies Experimental Studies in Volunteers Experimental Studies in Patients Early Clinical Trials Controlled Clinical Trials Marketing Early and Late Clinical Evaluation4 Antischizophrenic Drugs Introduction Nomenclature Unconventional Chemotherapy Pharmacology Non-DA-Related Pharmacology Pharmacokinetics Clinical Efficacy Unwanted Effects5 Antiparkinsonian and Antidyskinetic Drugs Introduction Pathophysiology of Neuroleptic-Induced Movement Disorders Drug Treatment of Neuroleptic-Induced Movement Disorders6 Antianxiety Drugs Generalized Central Anxiolytics (Sedative Drugs) Specific Central Anxiolytics (Ataractic Drugs) Peripheral Anxiolytics Comparison of Antianxiety Drugs7 Tricyclic Antidepressants Introduction Pharmacology Pharmacokinetics Clinical Use Introduction of Amitriptyline Other Tricyclic Antidepressant Drugs Comparisons Between Tricyclic Drugs and Other Antidepressive Treatments Tricyclic Drugs in the Treatment of Enuresis General Topics Concerning the Tricyclic Drugs Unwanted Effects8 New Generation of Antidepressants Tricyclic Antidepressants MAO Inhibitors Maprotiline Mianserin Viloxazine Flupenthixol Nomifensine Trazadone Zimelidine Comments Summary9 Monoamine Oxidase Inhibitors and Amine Precursors Pharmacology Pharmacokinetics Clinical Use Dosage and Clinical Response Unwanted Effects Individual Monoamine Oxidase Inhibitors Main Clinical Indications for Maois Amine Precursors10 Lithium Carbonate Introduction and Historical Aspects Pharmacology Pharmacokinetics Determination of Lithium Concentration Lithium Preparations Clinical Use Treatment of Depression with Lithium Lithium and Schizoaffective Disorders Lithium and Other Conditions Unwanted Effects Drug Interactions Unwanted and Toxic Effects of Lithium11 Psychostimulants Introduction Pharmacology Pharmacokinetics Clinical Efficacy Adverse Effects Methylphenidate Other Psychostimulants Fenfluramine Caffeine Drug Interactions12 Drugs of Dependence Controlled Drugs Opiate Drugs Tobacco Smoking and Nicotine Dependence Amphetamines Hallucinogens Solvent Abuse Minor Analgesic Abuse Non-Barbiturate Sedatives Barbiturates Cannabis Cocaine13 Alcohol Historical Background Ethanol Metabolism Ethanol Oxidation Problem Drinking Tolerance and Pharmacological Dependence Alcohol and Women Ethanol and the Neuronal Membrane The Fetal Alcohol Syndrome Hangover and the Role of Congeners Clinical Use of Ethanol Drug Interactions Drug Treatment for Problem Drinking14 Drugs in Child Psychiatry Pharmacokinetics Pharmacodynamics Antianxiety Drugs Tricyclic Antidepressants Monoamine Oxidase Inhibitors Amine Precursors Lithium Carbonate Psychostimulants Summary of Clinical Use Unwanted Effects of Psychotropic Drugs in Children15 Drugs in Psychogeriatrics Introduction Pharmacokinetic and Pharmacodynamic Aspects of Aging Other Aspects of Aging of Relevance to Psychotropic Drug Therapy Unwanted Effects of Psychotropic Drugs-Some General Principles Antidepressant Drugs and the Treatment of Depression Minor Tranquillizers and the Treatment of Anxiety and Insomnia Major Tranquillizers and the