Senotherapeutics

This book provides a comprehensive overview of the emerging field of senotherapeutics and its potential applications in various diseases. The initial chapter elucidates the central role of cellular senescence and the senescence-associated secretory phenotype (SASP) in the intricate balance between health and disease. The subsequent chapter examines the origin of senotherapeutics, introducing the concepts of senolytics and senomorphics for combating senescence and its associated disorders. The book also focuses on the potential of senotherapeutics in managing neurological disorders and neurodegenerative diseases. Furthermore, it investigates the intersection of senotherapeutics with cancer therapy, shedding light on innovative treatments and their role against cancer. It also discusses the broader role of senotherapeutics in aging and its associated disorders such as osteoporosis and osteoarthritis, offering insights into their implications for geriatric medicine. The book reviews the novel application of senotherapeutics in skincare and dermatological diseases, as well as metabolic disorders. This book is intended for researchers in the fields of biomedicine, pharmacology, and gerontology, as well as healthcare professionals. Key Features - Offers a comprehensive exploration of senotherapeutics, spanning various diseases and conditions, providing a holistic understanding of its potential applications. - Provides a conceptual framework for cellular senescence and the senescence-associated secretory phenotype (SASP) and their relevance to health and disease. - Examines the potential of senotherapeutics in addressing neurological disorders, neurodegenerative diseases, and cancer therapy. - Explores the broader role of senotherapeutics in the context of aging and associated disorders such as osteoarthritis and osteoporosis. - Reviews the application of senotherapeutics in skincare and dermatological concerns, as well as metabolic disorders.

Razia Khanam holds both an M.Pharm. and a Ph.D. degree from Jamia Hamdard University, New Delhi, India. Currently positioned as a professor specializing in pharmacology at Gulf Medical University in Ajman, UAE, she boasts an extensive tenure of 23 years in the realms of teaching and research. Her scholarly contributions have garnered significant attention, amassing over 1110 citations. She also holds the distinction of being an esteemed member of the editorial boards of various renowned journals. Her accomplishments further encompass accolades such as the 1999 Gold Medal from Jamia Hamdard and the Career Award for Young Scientists conferred by the All-India Council for Technical Education (AICTE). Divya Vohora holds the position of Professor of Pharmacology in the School of Pharmaceutical Education and Research (SPER) at Jamia Hamdard University, New Delhi. With over 25 years of teaching and research experience, she has served in various roles such as head of the Department for Pharmacology, assistant dean for student's welfare, director of the Department of Distance and Online Learning (DODL), and in-charge of Pharmaceutical Medicine (a collaborative doctoral program with Sun Pharmaceuticals). She has published more than 200 research articles in both national and international journals of high repute and has authored and edited five books. She has earned prestigious fellowships throughout her career. She is an Elected Fellow of the National Academy of Medical Sciences (FAMS) in India, a Fellow of the Indian Pharmacological Society (FIPS), a Fellow of the British Pharmacological Society (FBPhS), and a Fellow of the Royal Society of Biology in the UK (FRSB). She has received numerous awards in recognition of her outstanding work, including the Dr. B. K. Anand Oration Award, the Dr. Vinod Kumar Bhargava Award from the National Academy of Medical Sciences (NAMS), the Distinguished Woman Scientist Award from the ISCB, the Dr. D. N. Prasad Memorial Oration Award from ICMR, the Career Award for Young Teachers from AICTE, and the Fast Track Award for Young Scientists from DST, Government of India, among others. She also plays an active role on the international stage, serving as a member of the International Advisory Group of the British Pharmacological Society in the UK and as an expert member evaluating research grants submitted to institutions like the National Science Centre in Poland and the La Caixa Foundation in Spain. Her primary areas of research interest are in neuropharmacology, with a particular focus on epilepsy, neurodegenerative diseases (including Alzheimer's disease), and their associated co-morbidities including bone diseases.

1 Origin of Senotherapeutics: Senolytics and Senomorphics; 2 Senotherapeutics in Neurological Disorders; 3 Senolytics in Skin Care and Skin Diseases; 4 Senotherapeutics in Cancer; 5 Senotherapeutics in Aging and Age-Associated Disorders; 6 An Emerging Approach of Senotherapeutics for the Treatment of Lung Disorders: Molecular Mechanisms and Therapeutic Potential; 7 Senotherapeutics in Bone Disorders; 8 Senotherapeutics and Diabetes; 9 Bringing Senotherapeutics from Research to Patient Care: Status and Challenges