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Lipids and Skin Health is the first effort to summarize and review the studies, ideas, and research that link lipid metabolism to the largest organ of our body, the skin. The book covers the fundamental biology of the skin, and the major involvement of the transcriptional factors that govern lipid synthesis and the bioactive lipids in this intriguing organ. All layers of skin are presented, as well as their relevant lipids from the epidermis to dermis and even to the hypodermis. The important and unique-to-skin biological pathways are laid out, with a special focus on the various models that demonstrate the essential role of lipid synthesis in skin pathophysiology. The use of lipids in the cosmetic industry is emphasized, and last but not least the involvement of lipids in the clinical setting is also discussed. This book will appeal to healthcare professionals, researchers and dermatology professionals, and will help them to brainstorm new products and opportunities that will target the emerging importance of lipid metabolism in skin for acne, aging, and healthy skin. About the Editor Apostolos Pappas, Ph.D., is a professional member of the Institute of Food Technology. He started his professional career as a research biochemist in the Skin Research Center of Johnson & Johnson and later served as a group leader at Munich Biotech, where he worked on cancer research. Thereafter he returned to Johnson & Johnson, where he is currently a Research Manager and Fellow focusing on lipid metabolism research. He has authored numerous scientific publications, patent applications, and books.
Apostolos Pappas, Ph.D., is a professional member of the Institute of Food Technology. He started his professional career as a research biochemist in the Skin Research Center of Johnson & Johnson and later served as a group leader at Munich Biotech, where he worked on cancer research. Thereafter he returned to Johnson & Johnson, where he is currently a Research Manager and Fellow focusing on lipid metabolism research. He has authored numerous scientific publications, patent applications, and books.
1. Editor's Introduction: Skin lipids (epidermal, sebaceous, subcutaneous).- 2. Skin basics, structure and function.- 3. Skin barrier, structure and properties.- 4. Lipid oxidation and mediators in skin.- 5. Skin Ceramides.- 6. Cholesterol synthesis in epidermis.- 7. Transcriptional factors and epidermal differentiation.- 8. The brain of the skin: sebaceous gland.- 9. Sebaceous lipids.- 10. Sapienic acid and sebum specific fatty acid metabolism.- 11. Wax Esters chemistry and synthesis.- 12. Squalene chemistry and biology.- 13. Adipose tissue and fat cell biology.- 14. acial subcutaneous tissue.- 15. Monounsaturated fatty acid synthesis genes and skin/hair.- 16. Triglyceride synthesis genes and skin/hair.- 17. Lipoxygenase and skin.- 18. PPAR gamma receptor, skin lipids and hair.- 19. Mineral oils in skincare.- 20. Lipophilic antioxidants and skincare.- 21. Glycerol, Fatty alcohols, acids and esters in cosmetics.- 22. Vegetable and natural oils in cosmetics.- 23. Acne and lipid pathways.- 24. Atopic dermatitis and lipids.
